Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment
Identifieur interne : 000445 ( Main/Corpus ); précédent : 000444; suivant : 000446Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment
Auteurs : P. O. Valko ; D. Waldvogel ; M. Weller ; C. L. Bassetti ; U. Held ; C. R. BaumannSource :
- European Journal of Neurology [ 1351-5101 ] ; 2010-12.
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- KwdEn :
Abstract
Background and purpose: A comprehensive study of both fatigue and excessive daytime sleepiness (EDS) in association with Parkinson’s disease (PD)‐related symptoms and treatment has not been performed yet. To assess the frequency and severity of fatigue and EDS in patients with idiopathic PD and to study their relation to motor and non‐motor symptoms and dopaminergic treatment. Methods: We prospectively assessed Fatigue Severity Scale (FSS) scores, Epworth Sleepiness Scale (ESS) scores, Beck Depression Inventory (BDI) scores, severity (Unified PD Rating Scale, UPDRS, part III; Hoehn & Yahr staging) and duration of the disease, and the current dopaminergic treatment in 88 consecutive patients with idiopathic PD. Results: Fatigue was found in 52 (59%), EDS in 42 (48%), and both complaints in 31 (35%) patients. Fatigued patients had higher UPDRS III scores (23.5 ± 11.1 vs. 18.6 ± 7.6, P = 0.03), higher Hoehn & Yahr staging (2.4 ± 0.9 vs. 2.1 ± 0.7, P = 0.03), and higher BDI scores (13.4 ± 7.1 vs. 9.1 ± 5.8, P = 0.004) than non‐fatigued patients. In contrast, UPDRS III, Hoehn & Yahr, and BDI scores did not differ between patients with or without EDS. However, the type of dopaminergic treatment (levodopa monotherapy versus combination of levodopa/dopamine agonists) was associated with significant differences in ESS (8.5 ± 5.2 vs. 10.8 ± 4.3, P = 0.04), but not FSS scores (4.1 ± 1.5 vs. 4.3 ± 1.5, P = 0.55). Disease duration correlated with ESS scores (r = 0.32, P = 0.003), but not with FSS scores (r = −0.02, P = 0.82). Conclusions: In PD, there is a significant overlap of fatigue and EDS, but the two symptoms are differently correlated with the severity of motor symptoms, disease duration, depression, and dopaminergic treatment.
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DOI: 10.1111/j.1468-1331.2010.03063.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment</title><author><name sortKey="Valko, P O" sort="Valko, P O" uniqKey="Valko P" first="P. O." last="Valko">P. O. Valko</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation></author><author><name sortKey="Waldvogel, D" sort="Waldvogel, D" uniqKey="Waldvogel D" first="D." last="Waldvogel">D. Waldvogel</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation></author><author><name sortKey="Weller, M" sort="Weller, M" uniqKey="Weller M" first="M." last="Weller">M. Weller</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation></author><author><name sortKey="Bassetti, C L" sort="Bassetti, C L" uniqKey="Bassetti C" first="C. L." last="Bassetti">C. L. Bassetti</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurocenter of Southern Switzerland, Lugano, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Held, U" sort="Held, U" uniqKey="Held U" first="U." last="Held">U. Held</name><affiliation><mods:affiliation>Horton Centre for Patient‐oriented Research, University Hospital of Zurich, Zurich:</mods:affiliation></affiliation></author><author><name sortKey="Baumann, C R" sort="Baumann, C R" uniqKey="Baumann C" first="C. R." last="Baumann">C. R. Baumann</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6206A2ABB7F6683BD83D5673119E9D298BDBFBF6</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1468-1331.2010.03063.x</idno><idno type="url">https://api.istex.fr/document/6206A2ABB7F6683BD83D5673119E9D298BDBFBF6/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000445</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment</title><author><name sortKey="Valko, P O" sort="Valko, P O" uniqKey="Valko P" first="P. O." last="Valko">P. O. Valko</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation></author><author><name sortKey="Waldvogel, D" sort="Waldvogel, D" uniqKey="Waldvogel D" first="D." last="Waldvogel">D. Waldvogel</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation></author><author><name sortKey="Weller, M" sort="Weller, M" uniqKey="Weller M" first="M." last="Weller">M. Weller</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation></author><author><name sortKey="Bassetti, C L" sort="Bassetti, C L" uniqKey="Bassetti C" first="C. L." last="Bassetti">C. L. Bassetti</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurocenter of Southern Switzerland, Lugano, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Held, U" sort="Held, U" uniqKey="Held U" first="U." last="Held">U. Held</name><affiliation><mods:affiliation>Horton Centre for Patient‐oriented Research, University Hospital of Zurich, Zurich:</mods:affiliation></affiliation></author><author><name sortKey="Baumann, C R" sort="Baumann, C R" uniqKey="Baumann C" first="C. R." last="Baumann">C. R. Baumann</name><affiliation><mods:affiliation>Department of Neurology</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-12">2010-12</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1428">1428</biblScope><biblScope unit="page" to="1436">1436</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">6206A2ABB7F6683BD83D5673119E9D298BDBFBF6</idno><idno type="DOI">10.1111/j.1468-1331.2010.03063.x</idno><idno type="ArticleID">ENE3063</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>depression</term><term>disease duration</term><term>dopaminergic treatment</term><term>excessive daytime sleepiness</term><term>fatigue</term><term>idiopathic Parkinson’s disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and purpose: A comprehensive study of both fatigue and excessive daytime sleepiness (EDS) in association with Parkinson’s disease (PD)‐related symptoms and treatment has not been performed yet. To assess the frequency and severity of fatigue and EDS in patients with idiopathic PD and to study their relation to motor and non‐motor symptoms and dopaminergic treatment. Methods: We prospectively assessed Fatigue Severity Scale (FSS) scores, Epworth Sleepiness Scale (ESS) scores, Beck Depression Inventory (BDI) scores, severity (Unified PD Rating Scale, UPDRS, part III; Hoehn & Yahr staging) and duration of the disease, and the current dopaminergic treatment in 88 consecutive patients with idiopathic PD. Results: Fatigue was found in 52 (59%), EDS in 42 (48%), and both complaints in 31 (35%) patients. Fatigued patients had higher UPDRS III scores (23.5 ± 11.1 vs. 18.6 ± 7.6, P = 0.03), higher Hoehn & Yahr staging (2.4 ± 0.9 vs. 2.1 ± 0.7, P = 0.03), and higher BDI scores (13.4 ± 7.1 vs. 9.1 ± 5.8, P = 0.004) than non‐fatigued patients. In contrast, UPDRS III, Hoehn & Yahr, and BDI scores did not differ between patients with or without EDS. However, the type of dopaminergic treatment (levodopa monotherapy versus combination of levodopa/dopamine agonists) was associated with significant differences in ESS (8.5 ± 5.2 vs. 10.8 ± 4.3, P = 0.04), but not FSS scores (4.1 ± 1.5 vs. 4.3 ± 1.5, P = 0.55). Disease duration correlated with ESS scores (r = 0.32, P = 0.003), but not with FSS scores (r = −0.02, P = 0.82). Conclusions: In PD, there is a significant overlap of fatigue and EDS, but the two symptoms are differently correlated with the severity of motor symptoms, disease duration, depression, and dopaminergic treatment.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>P. O. Valko</name><affiliations><json:string>Department of Neurology</json:string></affiliations></json:item><json:item><name>D. Waldvogel</name><affiliations><json:string>Department of Neurology</json:string></affiliations></json:item><json:item><name>M. Weller</name><affiliations><json:string>Department of Neurology</json:string></affiliations></json:item><json:item><name>C. L. Bassetti</name><affiliations><json:string>Department of Neurology</json:string><json:string>Neurocenter of Southern Switzerland, Lugano, Switzerland</json:string></affiliations></json:item><json:item><name>U. Held</name><affiliations><json:string>Horton Centre for Patient‐oriented Research, University Hospital of Zurich, Zurich:</json:string></affiliations></json:item><json:item><name>C. R. Baumann</name><affiliations><json:string>Department of Neurology</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>disease duration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopaminergic treatment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>excessive daytime sleepiness</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fatigue</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>idiopathic Parkinson’s disease</value></json:item></subject><articleId><json:string>ENE3063</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background and purpose: A comprehensive study of both fatigue and excessive daytime sleepiness (EDS) in association with Parkinson’s disease (PD)‐related symptoms and treatment has not been performed yet. To assess the frequency and severity of fatigue and EDS in patients with idiopathic PD and to study their relation to motor and non‐motor symptoms and dopaminergic treatment. Methods: We prospectively assessed Fatigue Severity Scale (FSS) scores, Epworth Sleepiness Scale (ESS) scores, Beck Depression Inventory (BDI) scores, severity (Unified PD Rating Scale, UPDRS, part III; Hoehn & Yahr staging) and duration of the disease, and the current dopaminergic treatment in 88 consecutive patients with idiopathic PD. Results: Fatigue was found in 52 (59%), EDS in 42 (48%), and both complaints in 31 (35%) patients. Fatigued patients had higher UPDRS III scores (23.5 ± 11.1 vs. 18.6 ± 7.6, P = 0.03), higher Hoehn & Yahr staging (2.4 ± 0.9 vs. 2.1 ± 0.7, P = 0.03), and higher BDI scores (13.4 ± 7.1 vs. 9.1 ± 5.8, P = 0.004) than non‐fatigued patients. In contrast, UPDRS III, Hoehn & Yahr, and BDI scores did not differ between patients with or without EDS. However, the type of dopaminergic treatment (levodopa monotherapy versus combination of levodopa/dopamine agonists) was associated with significant differences in ESS (8.5 ± 5.2 vs. 10.8 ± 4.3, P = 0.04), but not FSS scores (4.1 ± 1.5 vs. 4.3 ± 1.5, P = 0.55). Disease duration correlated with ESS scores (r = 0.32, P = 0.003), but not with FSS scores (r = −0.02, P = 0.82). Conclusions: In PD, there is a significant overlap of fatigue and EDS, but the two symptoms are differently correlated with the severity of motor symptoms, disease duration, depression, and dopaminergic treatment.</abstract><qualityIndicators><score>8</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1756</abstractCharCount><pdfWordCount>5324</pdfWordCount><pdfCharCount>33376</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>250</abstractWordCount></qualityIndicators><title>Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment</title><genre><json:string>article</json:string></genre><host><volume>17</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>9</total><last>1436</last><first>1428</first></pages><issn><json:string>1351-5101</json:string></issn><issue>12</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1111/j.1468-1331.2010.03063.x</json:string></doi><id>6206A2ABB7F6683BD83D5673119E9D298BDBFBF6</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/6206A2ABB7F6683BD83D5673119E9D298BDBFBF6/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/6206A2ABB7F6683BD83D5673119E9D298BDBFBF6/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/6206A2ABB7F6683BD83D5673119E9D298BDBFBF6/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment</title><author><persName><forename type="first">P. O.</forename><surname>Valko</surname></persName><affiliation>Department of Neurology</affiliation></author><author><persName><forename type="first">D.</forename><surname>Waldvogel</surname></persName><affiliation>Department of Neurology</affiliation></author><author><persName><forename type="first">M.</forename><surname>Weller</surname></persName><affiliation>Department of Neurology</affiliation></author><author><persName><forename type="first">C. L.</forename><surname>Bassetti</surname></persName><affiliation>Department of Neurology</affiliation><affiliation>Neurocenter of Southern Switzerland, Lugano, Switzerland</affiliation></author><author><persName><forename type="first">U.</forename><surname>Held</surname></persName><affiliation>Horton Centre for Patient‐oriented Research, University Hospital of Zurich, Zurich:</affiliation></author><author><persName><forename type="first">C. R.</forename><surname>Baumann</surname></persName><affiliation>Department of Neurology</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-12"></date><biblScope unit="volume">17</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1428">1428</biblScope><biblScope unit="page" to="1436">1436</biblScope></imprint></monogr><idno type="istex">6206A2ABB7F6683BD83D5673119E9D298BDBFBF6</idno><idno type="DOI">10.1111/j.1468-1331.2010.03063.x</idno><idno type="ArticleID">ENE3063</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background and purpose: A comprehensive study of both fatigue and excessive daytime sleepiness (EDS) in association with Parkinson’s disease (PD)‐related symptoms and treatment has not been performed yet. To assess the frequency and severity of fatigue and EDS in patients with idiopathic PD and to study their relation to motor and non‐motor symptoms and dopaminergic treatment. Methods: We prospectively assessed Fatigue Severity Scale (FSS) scores, Epworth Sleepiness Scale (ESS) scores, Beck Depression Inventory (BDI) scores, severity (Unified PD Rating Scale, UPDRS, part III; Hoehn & Yahr staging) and duration of the disease, and the current dopaminergic treatment in 88 consecutive patients with idiopathic PD. Results: Fatigue was found in 52 (59%), EDS in 42 (48%), and both complaints in 31 (35%) patients. Fatigued patients had higher UPDRS III scores (23.5 ± 11.1 vs. 18.6 ± 7.6, P = 0.03), higher Hoehn & Yahr staging (2.4 ± 0.9 vs. 2.1 ± 0.7, P = 0.03), and higher BDI scores (13.4 ± 7.1 vs. 9.1 ± 5.8, P = 0.004) than non‐fatigued patients. In contrast, UPDRS III, Hoehn & Yahr, and BDI scores did not differ between patients with or without EDS. However, the type of dopaminergic treatment (levodopa monotherapy versus combination of levodopa/dopamine agonists) was associated with significant differences in ESS (8.5 ± 5.2 vs. 10.8 ± 4.3, P = 0.04), but not FSS scores (4.1 ± 1.5 vs. 4.3 ± 1.5, P = 0.55). Disease duration correlated with ESS scores (r = 0.32, P = 0.003), but not with FSS scores (r = −0.02, P = 0.82). Conclusions: In PD, there is a significant overlap of fatigue and EDS, but the two symptoms are differently correlated with the severity of motor symptoms, disease duration, depression, and dopaminergic treatment.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>depression</term></item><item><term>disease duration</term></item><item><term>dopaminergic treatment</term></item><item><term>excessive daytime sleepiness</term></item><item><term>fatigue</term></item><item><term>idiopathic Parkinson’s disease</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/6206A2ABB7F6683BD83D5673119E9D298BDBFBF6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="12112"><doi origin="wiley">10.1111/ene.2010.17.issue-12</doi><numberingGroup><numbering type="journalVolume" number="17">17</numbering><numbering type="journalIssue" number="12">12</numbering></numberingGroup><coverDate startDate="2010-12">December 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2010.03063.x</doi><idGroup><id type="unit" value="ENE3063"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2010 The Author(s). European Journal of Neurology © 2010 EFNS</copyright><eventGroup><event type="firstOnline" date="2010-11-18"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-05-13"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.27 mode:FullText" date="2010-11-18"></event><event type="publishedOnlineFinalForm" date="2010-11-18"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1428">1428</numbering><numbering type="pageLast" number="1436">1436</numbering></numberingGroup><correspondenceTo>P. O. Valko, Department of Neurology, University Hospital of Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland (tel.: +41 44 255 55 11; fax: +41 44 255 43 80; e‐mail: <email>philipp.valko@usz.ch</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE3063.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 7 November 2009 Accepted 10 March 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="3"></count></countGroup><titleGroup><title type="main">Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment</title><title type="shortAuthors">P. O. Valko <i>et al.</i></title><title type="short">Fatigue and EDS in idiopathic PD</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>P. O.</givenNames><familyName>Valko</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>D.</givenNames><familyName>Waldvogel</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>M.</givenNames><familyName>Weller</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1 #a3"><personName><givenNames>C. L.</givenNames><familyName>Bassetti</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>U.</givenNames><familyName>Held</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>C. R.</givenNames><familyName>Baumann</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Neurology</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Horton Centre for Patient‐oriented Research, University Hospital of Zurich, Zurich:</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="CH"><unparsedAffiliation>Neurocenter of Southern Switzerland, Lugano, Switzerland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">depression</keyword><keyword xml:id="k2">disease duration</keyword><keyword xml:id="k3">dopaminergic treatment</keyword><keyword xml:id="k4">excessive daytime sleepiness</keyword><keyword xml:id="k5">fatigue</keyword><keyword xml:id="k6">idiopathic Parkinson’s disease</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background and purpose: </b> A comprehensive study of both fatigue and excessive daytime sleepiness (EDS) in association with Parkinson’s disease (PD)‐related symptoms and treatment has not been performed yet. To assess the frequency and severity of fatigue and EDS in patients with idiopathic PD and to study their relation to motor and non‐motor symptoms and dopaminergic treatment.</p><p><b>Methods: </b> We prospectively assessed Fatigue Severity Scale (FSS) scores, Epworth Sleepiness Scale (ESS) scores, Beck Depression Inventory (BDI) scores, severity (Unified PD Rating Scale, UPDRS, part III; Hoehn & Yahr staging) and duration of the disease, and the current dopaminergic treatment in 88 consecutive patients with idiopathic PD.</p><p><b>Results: </b> Fatigue was found in 52 (59%), EDS in 42 (48%), and both complaints in 31 (35%) patients. Fatigued patients had higher UPDRS III scores (23.5 ± 11.1 vs. 18.6 ± 7.6, <i>P </i>=<i> </i>0.03), higher Hoehn & Yahr staging (2.4 ± 0.9 vs. 2.1 ± 0.7, <i>P </i>=<i> </i>0.03), and higher BDI scores (13.4 ± 7.1 vs. 9.1 ± 5.8, <i>P </i>=<i> </i>0.004) than non‐fatigued patients. In contrast, UPDRS III, Hoehn & Yahr, and BDI scores did not differ between patients with or without EDS. However, the type of dopaminergic treatment (levodopa monotherapy versus combination of levodopa/dopamine agonists) was associated with significant differences in ESS (8.5 ± 5.2 vs. 10.8 ± 4.3, <i>P </i>=<i> </i>0.04), but not FSS scores (4.1 ± 1.5 vs. 4.3 ± 1.5, <i>P </i>=<i> </i>0.55). Disease duration correlated with ESS scores (<i>r </i>=<i> </i>0.32, <i>P </i>=<i> </i>0.003), but not with FSS scores (<i>r </i>=<i> </i>−0.02, <i>P </i>=<i> </i>0.82).</p><p><b>Conclusions: </b> In PD, there is a significant overlap of fatigue and EDS, but the two symptoms are differently correlated with the severity of motor symptoms, disease duration, depression, and dopaminergic treatment.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment</title></titleInfo><titleInfo type="abbreviated"><title>Fatigue and EDS in idiopathic PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment</title></titleInfo><name type="personal"><namePart type="given">P. O.</namePart><namePart type="family">Valko</namePart><affiliation>Department of Neurology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Waldvogel</namePart><affiliation>Department of Neurology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Weller</namePart><affiliation>Department of Neurology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. L.</namePart><namePart type="family">Bassetti</namePart><affiliation>Department of Neurology</affiliation><affiliation>Neurocenter of Southern Switzerland, Lugano, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Held</namePart><affiliation>Horton Centre for Patient‐oriented Research, University Hospital of Zurich, Zurich:</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. R.</namePart><namePart type="family">Baumann</namePart><affiliation>Department of Neurology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-12</dateIssued><edition>Received 7 November 2009 Accepted 10 March 2010</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent></physicalDescription><abstract lang="en">Background and purpose: A comprehensive study of both fatigue and excessive daytime sleepiness (EDS) in association with Parkinson’s disease (PD)‐related symptoms and treatment has not been performed yet. To assess the frequency and severity of fatigue and EDS in patients with idiopathic PD and to study their relation to motor and non‐motor symptoms and dopaminergic treatment. Methods: We prospectively assessed Fatigue Severity Scale (FSS) scores, Epworth Sleepiness Scale (ESS) scores, Beck Depression Inventory (BDI) scores, severity (Unified PD Rating Scale, UPDRS, part III; Hoehn & Yahr staging) and duration of the disease, and the current dopaminergic treatment in 88 consecutive patients with idiopathic PD. Results: Fatigue was found in 52 (59%), EDS in 42 (48%), and both complaints in 31 (35%) patients. Fatigued patients had higher UPDRS III scores (23.5 ± 11.1 vs. 18.6 ± 7.6, P = 0.03), higher Hoehn & Yahr staging (2.4 ± 0.9 vs. 2.1 ± 0.7, P = 0.03), and higher BDI scores (13.4 ± 7.1 vs. 9.1 ± 5.8, P = 0.004) than non‐fatigued patients. In contrast, UPDRS III, Hoehn & Yahr, and BDI scores did not differ between patients with or without EDS. However, the type of dopaminergic treatment (levodopa monotherapy versus combination of levodopa/dopamine agonists) was associated with significant differences in ESS (8.5 ± 5.2 vs. 10.8 ± 4.3, P = 0.04), but not FSS scores (4.1 ± 1.5 vs. 4.3 ± 1.5, P = 0.55). Disease duration correlated with ESS scores (r = 0.32, P = 0.003), but not with FSS scores (r = −0.02, P = 0.82). Conclusions: In PD, there is a significant overlap of fatigue and EDS, but the two symptoms are differently correlated with the severity of motor symptoms, disease duration, depression, and dopaminergic treatment.</abstract><subject lang="en"><genre>Keywords</genre><topic>depression</topic><topic>disease duration</topic><topic>dopaminergic treatment</topic><topic>excessive daytime sleepiness</topic><topic>fatigue</topic><topic>idiopathic Parkinson’s disease</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1428</start><end>1436</end><total>9</total></extent></part></relatedItem><identifier type="istex">6206A2ABB7F6683BD83D5673119E9D298BDBFBF6</identifier><identifier type="DOI">10.1111/j.1468-1331.2010.03063.x</identifier><identifier type="ArticleID">ENE3063</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 The Author(s). 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